Here is my personal bracket breakdown
Harley over Two-Face: HQ has the clear psychological advantage here. While Two-face is ruthless, hhe historically can be thrown into an overly emotional state of rage through taunting. This rage reduces his accuracy and allows HQ to gwt in the one knockout blow with baseball bat or mallet.
Poison Ivy over Kite-Man: Certainly if we take HQ Animated versions of these characters, it comes down to Ivy being more ruthless than KM. She has a vine wrap around him, crushing his kite and immobilizing him and KM taps out.
Dr. Pyscho over Killer Frost: The doc can literally get inside her head and Frosty has a lot of baggage. The doc uses that to his advantage. Another tap out, while Frosty screams "make it stop. I don’t want to think about all these repressed memories.
Mr. Nobody over Anton Arcade: AA is not ready for the Dadaism of Mr. N. The ridiculing the absurdity of existence just is to much for AA. It is a battle of philosophical ideals and Mr. N takes it.
Mr. Freeze over Clayface: Victor is to laser focused and ruthless to lose to Clayface. CF is often, especially early in battles, guilty of showing off what he can do. We aalso know that the one way to take down CF is by freezing. Yes, CF could take on the form of Mr. F’s wife, Nora, in an effort to get Victor to pause, but, Mr. F is ready for that ploy and just takes care of business. A quick and decisive win for Mr. F.
Scarecrow over Victor Zsasz: Zsasz may be a serial killer but he’s no green lantern and cannot overcome great fear. One of Scarecrows gas bombs, which Zsasz has no super powers to avoid, fills the arena and Zsasz is done for. Of course this means Scarecrow has gassed all those in attendance too…but, you can’t make an omelette without breaking a few eggs.
Star Sapphire over Hugo Strange: One would think Hugo would have the psychological advantage in this one, but, Carol really has the upper hand. She has no love for Hugo but plety of love for Hal and wants to demonstrate her power. That focus won’t be broken by H.S.'s psychological ploys. Yes, his phsyical appearance belies his advanced, but still human, levels of strength and agility. However, psychology is his greatest weapon and in a one-on-one matchup, he doesn’t get the advantage over Carol. She encase him in a form of suspended animation and match over.
Reverse-Flash over Condiment King: The only problem for Thawne here is if he can keep himself from laughing so hard he trips and knocks himself out. However, Thawne is focused on advancing, he’ll keep his laughter in check until after the 14 nanoseconds this match is gonna take. (Thanks to @Aylex for pointing out I missed this matchup earlier.)
There is the breakdown, IMO.