All the heroes… Including BATMAN, have certainly had there moments of great error, and great mistakes that risked lives and even risked the universe (as They know it, and as we know it). But what makes them great, is that even though mistakes are made… They never give up. They never back down.
As far as great DANGERS to the universe… any change in Superman’s character, or loss of his temper (example, when Lois Lane, son, or Parents are in great Danger) could be the end of us all!